Two studies in Africa add weight to the previous data showing the medicines used to treat HIV can reduce the risk of infection when they take on a daily basis.
The World Health Organization said that studies could have "enormous impact" on the prevention of HIV transmission.
The results were revealed on the eve of a Conference on AIDS in Rome.
"This is a major scientific breakthrough that re-confirms the essential role to play in the response to AIDS, antiretroviral medicine", said Michel Sidibé, executive director of the joint programme of the United Nations on HIV/AIDS (UNAIDS).
"These studies could help us reach the turning point in the HIV epidemic".
Hopes for futureA study carried out by the University of Washington, United States, followed by almost 5,000 couples in Kenya and Uganda, where a person has HIV and the other is not.
Continue reading the main storyIf it is currently trying to keep HIV negative does not renounce condoms still "final quote Lisa power Terrence Higgins Trust not infected person took a daily medicine for HIV (tenofovir), a combination of two drugs for HIV (tenofovir and emtricitabine), or a placebo pill."
There were 62% less HIV infections in the Group on the single drug and 73 per cent fewer HIV infections in the group that took the combination, in comparison with those who are given a sham pill.
The other trial, carried out by the centres of United States for Disease Control, followed by 1,200 HIV-negative heterosexual men and women in Botswana. They received a combination of once daily or placebo tablet. HIV drugs reduced the risk of getting HIV by around 63% overall.
A previous trial is that the combination of two HIV drugs reduced the risk of infection in homosexual and bisexual men by 44%. But a similar study in women at risk of infection with HIV at Kenya, Tanzania, and South Africa results disappointing.
New toolsThe charity of HIV, the Terrence Higgins Trust, described the latest findings as "really exciting".
Smooth power policy chief told the BBC: "pre-exposure prophylaxis is not going to be available during the night, but we are studying whether it is one of a number of things that can reduce the transmission of HIV".
But stressed that the results needed to be properly proven and tested.
"If it is currently trying to keep HIV negative does not renounce condoms still."
The who and UNAIDS recommend that people make decisions evidence reported on HIV prevention options.
They say that no single method is totally protection against HIV and ARVs for prevention should be combined with other HIV prevention methods, such as condoms.
"Effective new HIV prevention tools are urgently needed, and these studies could have an enormous impact on the prevention of heterosexual transmission," said Dr. Margaret Chan, Director-General which is.
"Will work with countries to use the new findings to protect men and women from HIV infection."
All the details of the studies will be presented at the meeting in Rome.
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